Preparation and characterization of Beta vulgaris pulp powder as a pharmaceutical excipient

Abstract:

Mouth dissolving tablet is the highly growing and highly accepted drug delivery system. In the present study, an attempt had been made to prepare fast dispersible tablets of diclofenac sodium using Beta vulgaris pulp powder as a pharmaceutical disintegrant. In the present investigation, wet granulation technique was used to prepare tablets, using microcrystalline cellulose as filler. Wet granulation technique is one of the most convenient and acceptable technology for preparation of fast dispersible tablets. Dispersible tablets of Diclofenac sodium were prepared with different concentrations viz; 2.5, 5, 7.5 and 10 % (w/w) of Beta vulgaris pulp powder and corn starch, and evaluated for physical parameters such as thickness, hardness, friability, weight variation, drug content, disintegration time and drug dissolution behavior. The formulated tablets had good appearance and better drug release properties. Studies indicated that the Beta vulgaris pulp powder is a good pharmaceutical adjuvant, specifically a disintegrating agent.

Key words: Beta vulgaris, disintegrant, pharmaceutical excipients, diclofenac sodium.