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Published on:2nd June 2010
Pharmacognosy Journal, 2010; 2(10):335–337
Original Article | doi:Nill

Screening for Cytotoxic activity of Methanol Extract of Putranjiva roxburghii Wall (Euphorbiaceae) Seeds


Authors and affiliation (s):

Raghavendra H.L1*, Prashith Kekuda T.R2, Valleesha N.C3, Sudharshan S.J3 and Chinmaya A3

1Department of Biochemistry, Kuvempu University- PG Center, Tholahunase, Shivagangothri, Davanagere – 577 002, Karnataka, India.

2Department of Microbiology, SRNMN College of Applied Sciences, NES Campus, Balraj Urs road, Shivamogga – 577201, Karnataka, India.

3Post Graduate Department of Studies and Research in Biochemistry, Jnanasahyadri, Kuvempu University, Shankaraghatta – 577451, Karnataka, India.

Abstract:

Screening of active compounds from plants lead to discover new medicinal drugs which have efficient protection and treatment roles against various diseases including cancer. The present study was designed to investigate the cytotoxicity of methanol extract of seeds of Putranjiva roxburghii Wall (Euphorbiaceae). The preliminary phytochemical screening of methanol extract showed the presence of phenols, alkaloids, saponins, steroids, flavonoids and glycosides. The extract showed cytotoxicity with LC50 of 427.74 μg/ml in brine shrimp lethality assay. Further studies on isolation of metabolites and their cytotoxicity are under investigation.

Key words: Artemia nauplii, brine shrimp lethality, cytotoxicity, Putranjiva roxburghii Wall.

 

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