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Published on:23rd Nov, 2012
Pharmacognosy Journal, 2012; 4(32):29-31
Research Article | doi:10.5530/pj.2012.32.6

Chemical constituents of Aglaia loheri


Authors and affiliation (s):

Ragasa Consolacion Y,1* Torres Oscar B,1 Shen Chien-Chang,2 Mejia Michelle Gayle R,3 Ferrer Regina Joyce3 and Jacinto Sonia D3

1Chemistry Department, De La Salle University, 2401 Taft Avenue, Manila 1004 Philippines and Center for Natural Sciences and Ecological Research, De La Salle University, 2401 Taft Avenue, Manila 1004 Philippines

2National Research Institute of Chinese Medicine, No 155-1, Sec. 2, Li-Nung St., Taipei 112, Taiwan

3Institute of Biology, College of Science, University of the Philippines, Diliman, Quezon City, Philippines

Abstract:

The dichloromethane extract of the leaves of Aglaia loheri afforded spinasterol (1), trilinolein (2) and phytyl fatty acid ester (3). The structures of 1-2 were identified by comparison of their 13C NMR data with those reported in the literature. Compounds 1, 2 and 3 were evaluated for cytotoxicity against the colon carcinoma (HCT 116) using the MTT assay. They exhibited moderate cytotoxicity against HCT 116 with IC50 values of 40.52, 46.73 and 40.06, respectively.

Keywords: Aglaia loheri, Meliaceae, spinasterol, trilinolein, phytyl fatty acid ester, cytotoxic.

 

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