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Anti-Nociceptive Synergism of Pregabalin and Xylopic acid Co-administration in Paclitaxel-induced Neuropathy: Isobolographic Analysis
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Published on:7th July 2015
Pharmacognosy Journal, 2015; 7(6):55-57
Original Article | doi:Nill

Anti-Nociceptive Synergism of Pregabalin and Xylopic acid Co-administration in Paclitaxel-induced Neuropathy: Isobolographic Analysis


Authors and affiliation (s):

Ameyaw Elvis Ofori1*, Woode Eric3, Kyei Samuel2, Biny Peter Robert3, Boampong Johnson Nyarko1

1Department of Biomedical and Forensic Sciences, School of Biological Sciences, College of Agriculture and Natural Sciences, University of Cape Coast, Cape Coast, Ghana.

2Department of Optometry, School of Physical Sciences, College of Agriculture and Natural Sciences, University of Cape Coast, Cape Coast, Ghana.

3Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

Abstract:

Background: Paclitaxel-induced neuropathy still remains a clinical problem for patients undergoing chemotherapy. Objective: The objective of the study was to determine the interaction between xylopic acid and pregabalinco-administration as well as their toxicity in paclitaxel-induced neuropathy. Materials and Methods: Neuropathic pain was induced in rats with 2 mg/kg of paclitaxel on alternative days for four days (days 0, 2, 4 and 6). Equi effective doses of xylopic acid and pregabalin that produced 50% anti-nociception (ED50) were determined from their log-dose response curves in the cold allodynia and thermal pain tests. Xylopic acid and pregabalin were again administered to rats in a fixed ratio combination (1:1) of their ED50’sin order to determine the experimental ED50 (Zexp) of the co-administered compounds. Isobolograms were constructed to compare the Zexp to a theoretical ED50 (Zadd). Blood samples from the various treatment groups of rats were collected for toxicological assessment of the co-administered compounds. Results: The Zexplay below the Zadd on the isobologram of the cold allodnia test. The co-administration exhibited additivity in the thermal pain test. The co-administration did not produce significant (p>0.05) toxicity in rats. The co-administration may be beneficial in paclitaxel-induced neuropathy.

Key words: Isobolograms, Neuropathic pain, Paclitaxel, xylopic acid, Toxicity.

 

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