Home | Articles
Published on:29th Apr, 2015
Pharmacognosy Journal, 2015; 7(4):228-235
Original Article | doi:10.5530/pj.2015.4.4

Hepatoprotective Activity of Michelia nilagirica against Paracetamol Induced Hepatic Injury in Rats

Authors and affiliation (s):

Shaik Aminabee1, Atmakuri Lakshmana Rao*1 and Maram Chinna Eswaraiah2

1Department of Pharmacology, V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, Andhra Pradesh, INDIA

2Department of Pharmacognosy, Anurag College of Pharmacy, Kodad, Telangana, INDIA.


Background: Michelia nilagirica belonging to the family Mangoliaceae is commonly used by many traditional healers in most of the herbal preparations for diabetes and kidney diseases. Objective: Different fractions isolated from ethanolic extract of whole plant of Michelia nilagirica is investigated for hepatoprotective activity in wistar albino rats against paracetamol induced hepatic injury. Materials & Methods: Rats were divided into eight groups. Each group contains six animals. Hepatic injury was achieved by injecting paracetamol at a dose of 2 mg/kg p.o. Results: The hepatoprotective action is seen with fraction A by reduction in serum marker enzymes like Aspartate transaminase (AST), Alanine transaminase (ALT). It also reduced the elevated levels of Alkaline phosphotase (ALP) & Serum bilirubin. Conclusion: Histopathological studies further confined the hepatoprotective activity of fraction A against paracetamol treated group. The results obtained were compared with silymarin (100 mg/kg, orally), a standard drug.

Key words: Albino rats, Hepatoprotective, Michelia nilagirica, Paracetamol, Screening.


Articles in PDF, ePUB and Full text are attached to this page. In order to download, print or access these formats you must be logged in.


Article Links